Epithelial barrier dysfunction in ocular allergy

N Singh, Y Diebold, SK Sahu, A Leonardi - Allergy, 2022 - Wiley Online Library
… whereas claudin-10 was predominant in conjunctival epithelium. Reduced structural
proteins in the conjunctival epithelium in allergic eye disease. The expression of …

TFOS Lifestyle: impact of nutrition on the ocular surface

M Markoulli, S Ahmad, J Arcot, R Arita… - The ocular …, 2023 - Elsevier
… (carbohydrates, lipids, and proteins), micronutrients (vitamins and minerals) and water. All
nutrients serve as a source of energy, provide structural support to the body and/or regulate …

IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation

J Hu, N Gao, Y Zhang, X Chen, J Li, F Bian, W Chi… - Mucosal …, 2020 - nature.com
… the decreased expression of TJ protein JAM-A and AJ protein … AJCs structure proteins,
including ZO-1, claudin 1, occludin, … and conjunctival epithelia integrity in allergic inflammation …

Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery

S Kaur, P Sohnen, S Swamynathan, Y Du, EM Espana… - The Ocular Surface, 2023 - Elsevier
… continuous epithelial structure comprised of the cornea, the conjunctiva, … tissue is less stratified
with 3–4 layers of epithelial cells … Mechanistically, pollen-induced allergic conjunctivitis is …

[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

AL Onugwu, CS Nwagwu, OS Onugwu… - Journal of Controlled …, 2023 - Elsevier
… applied ocular medications such as eye drops is typically less … Other ASED such as dry eye
diseases and conjunctivitis, though … Conjunctivitis can be caused by allergens, infections or …

The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling

F Yang, D Fan, X Yang, F Zhu, M Shao, Q Li… - Acta Pharmacologica …, 2021 - nature.com
… The thread was placed on the lower conjunctival fornix at … of goblet cells in the conjunctival
epithelium of SCOP-injected … NLRP3 protein accumulated in the basal layer of conjunctival

Comparison of cytokine mediators in type 2 inflammatory conditions on the skin and ocular surface

J Chen, L Bielory - Current Opinion in Allergy and Clinical …, 2022 - ingentaconnect.com
… in the ocular epithelium of EAC mice exposed to ragweed pollen, … of tight junctions and other
structural proteins [70,71… , and reduced goblet cell density were observed in the conjunctiva. …

[HTML][HTML] Preserved Ophthalmic Anti-Allergy Medication in Cumulatively Increasing Risk Factors of Corneal Ectasia

T Paterson, S Azizoglu, M Gokhale, M Chambers… - Biology, 2023 - mdpi.com
… can severely decrease the integrity of the corneal structure when … end of the corneal and
conjunctival epithelium. This layer (… the expression of inflammatory proteins, atopic degradation …

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: cell and nuclear effects

NA Sharif - Biofactors, 2022 - Wiley Online Library
… on the corneal and conjunctival epithelia provides oxygen, … and conjunctival tissues is
triggering more eye allergies and … Since both drugs were equally effective in reducing ocular

TNF is a critical cytokine in age-related dry eye disease

Y Kelagere, KK Scholand, EN DeJong, AI Boyd, Z Yu… - The Ocular Surface, 2023 - Elsevier
… tight junction proteins are disrupted in aged conjunctiva [54]. … low in healthy control individuals
but increase in allergicdecreased ectopic lymphoid structures and decreased mRNA of …